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Getting Started

ESQhtpbpk.Rmd

Introduction

The high-throughput (HT) physiologically-based (PB) pharmacokinetics (PK) modeling framework is distributed as an R package that enables the prediction of pharmacokinetics profiles for various molecules across different species. It leverages the capability of the OSP Suite PK-Sim software through the use of {ospsuiteR} package.

Main Features

The ESQhtpbpk package is designed to facilitate the creation of HT-PBPK pipelines and their simulation. To this end, it:

  • Allows efficient and parallel execution of many compound PK predictions (via the {ospsuiteR} package).
  • Can automatically create various generic models as needed (limited to PK-Sim components).
  • Can be used with custom PKML files for additional specificities.

Running the framework

To run the framework with the automatic creation of generic models, refer to the following: vignette("ESQhtpbpk-automatic-models").

To run the framework with custom PKML files, refer to the following: vignette("ESQhtpbpk-custom-pkml").